gttf.uchc.eduHome | Center for Mouse Genome Modification

Skip to Navigation Skip to UConn Search Skip to Content UConn Health Search University of Connecticut A to Z Index Center for Mouse Genome Modification Search this Site Search in https://health.uconn.edu/mouse-genome-modification/> Search Toggle navigation Menu Center for Mouse Genome Modification Skip to content Home Services Services Service Request Forms Fees Fees for Mouse Genomic Modification Projects Fees for Other Services Payment Policy Protocols BAC DNA for Injection DNA Preparation for PCR Product Less Than 500 Bp Ear Punches, Yolk Sacs, Tail DNA for PCR Embryonic Stem Cell DNA Extraction from 96 Well Plates HOTSHOT Method of DNA Preparation PCR Genotyping for Gene Targeting F1 Mice PCR Screening for Targeted Stem Cell Colonies in 96 Well Plates Tail DNA Extraction Publications Using CMGM Mice Resources Mouse Embryonic Stem Cells Gene Targeting Vectors Conditional Knock-out/Expression Vectors Inbred Versus Outbred Strains Genetic Stability of Inbred Mice Congenic Mouse Strains Transgene Copy Numbers Reference Books Gene Targeting Related Publications Useful Links Contact Us Meet Our Team Contact Us Search this Site Search in https://health.uconn.edu/mouse-genome-modification/> Search The Center for Mouse Genome Modification (CMGM) at UConn Health provides design and generation of genetically modified mice and other services. CMGM Mice on Cover of Journal of Biological Chemistry Posted on September 7, 2018 September 7, 2018 by dmc04013 A rare mutation in a gene causes weak bones in mice and people – but not for the reasons you might expect. UConn researchers report in the September 7, 2018 issue of the Journal of Biological Chemistry how this mutation creates more bone-making cells but results in less bone, and find intriguing hints as to how the gene might affect other conditions as diverse as breast cancer and dementia. See full story from UConn Today. CMGM Mice on Lead Story of UConn Today Posted on February 16, 2018 May 22, 2018 by dmc04013 Bone-forming cells inside a living bone from a newborn mouse. In a recently published study in eLife, Leia Shuhaibar and others at UConn Health showed that these cells produce less cyclic GMP under conditions that resemble those in people with achondroplasia (dwarfism). Understanding how cyclic GMP production is regulated could contribute to improved therapies for achondroplasia. Read full story. (more…) A-Z Index UConn Health Disclaimer, Privacy Notice & Copyright Accessibility -- Maps & Directions © UConn Health Webmaster Login...